ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Antonios Chronopoulos; Benjamin Robinson; Muge Sarper; Ernesto Cortes; Vera Auernheimer; Dariusz Lachowski; Simon Attwood; Rebeca García; Saba Ghassemi; Ben Fabry; Armando del Río Hernández

doi:10.1038/ncomms12630

Nature Communications (Sep 2016)

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Antonios Chronopoulos,
Benjamin Robinson,
Muge Sarper,
Ernesto Cortes,
Vera Auernheimer,
Dariusz Lachowski,
Simon Attwood,
Rebeca García,
Saba Ghassemi,
Ben Fabry,
Armando del Río Hernández

Affiliations

Antonios Chronopoulos: Department of Bioengineering, Cellular and Molecular Biomechanics Laboratory, Imperial College London
Benjamin Robinson: Department of Bioengineering, Cellular and Molecular Biomechanics Laboratory, Imperial College London
Muge Sarper: Department of Bioengineering, Cellular and Molecular Biomechanics Laboratory, Imperial College London
Ernesto Cortes: Department of Bioengineering, Cellular and Molecular Biomechanics Laboratory, Imperial College London
Vera Auernheimer: Department of Physics, Biophysics Group, University of Erlangen-Nuremberg
Dariusz Lachowski: Department of Bioengineering, Cellular and Molecular Biomechanics Laboratory, Imperial College London
Simon Attwood: Department of Bioengineering, Cellular and Molecular Biomechanics Laboratory, Imperial College London
Rebeca García: Department of Bioengineering, Cellular and Molecular Biomechanics Laboratory, Imperial College London
Saba Ghassemi: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
Ben Fabry: Department of Physics, Biophysics Group, University of Erlangen-Nuremberg
Armando del Río Hernández: Department of Bioengineering, Cellular and Molecular Biomechanics Laboratory, Imperial College London

DOI: https://doi.org/10.1038/ncomms12630
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homeostasis of the tumour microenvironment. Here the authors show that all-trans retinoic acid reduces retinoic acid receptor beta dependent-actomyosin contractility and restores mechanical quiescence in PSCs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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