Membrane thickness, lipid phase and sterol type are determining factors in the permeability of membranes to small solutes

Jacopo Frallicciardi; Josef Melcr; Pareskevi Siginou; Siewert J. Marrink; Bert Poolman

doi:10.1038/s41467-022-29272-x

Nature Communications (Mar 2022)

Membrane thickness, lipid phase and sterol type are determining factors in the permeability of membranes to small solutes

Jacopo Frallicciardi,
Josef Melcr,
Pareskevi Siginou,
Siewert J. Marrink,
Bert Poolman

Affiliations

Jacopo Frallicciardi: Department of Biochemistry, University of Groningen
Josef Melcr: Department of Biophysical Chemistry, University of Groningen
Pareskevi Siginou: Department of Biochemistry, University of Groningen
Siewert J. Marrink: Department of Biophysical Chemistry, University of Groningen
Bert Poolman: Department of Biochemistry, University of Groningen

DOI: https://doi.org/10.1038/s41467-022-29272-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Membrane permeability of small molecules depends on the composition of the lipid bilayer. Here, authors compare permeability measured on membranes in different physical states and conclude that the yeast membrane exists in a highly ordered phase.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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