PorZ, an Essential Component of the Type IX Secretion System of
<i>Porphyromonas gingivalis</i>
, Delivers Anionic Lipopolysaccharide to the PorU Sortase for Transpeptidase Processing of T9SS Cargo Proteins

Mariusz Madej; Zuzanna Nowakowska; Miroslaw Ksiazek; Anna M. Lasica; Danuta Mizgalska; Magdalena Nowak; Anna Jacula; Monika Bzowska; Carsten Scavenius; Jan J. Enghild; Joseph Aduse-Opoku; Michael A. Curtis; F. Xavier Gomis-Rüth; Jan Potempa

doi:10.1128/mBio.02262-20

mBio (Feb 2021)

PorZ, an Essential Component of the Type IX Secretion System of <i>Porphyromonas gingivalis</i> , Delivers Anionic Lipopolysaccharide to the PorU Sortase for Transpeptidase Processing of T9SS Cargo Proteins

Mariusz Madej,
Zuzanna Nowakowska,
Miroslaw Ksiazek,
Anna M. Lasica,
Danuta Mizgalska,
Magdalena Nowak,
Anna Jacula,
Monika Bzowska,
Carsten Scavenius,
Jan J. Enghild,
Joseph Aduse-Opoku,
Michael A. Curtis,
F. Xavier Gomis-Rüth,
Jan Potempa

Affiliations

Mariusz Madej: ORCiD; Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
Zuzanna Nowakowska: Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
Miroslaw Ksiazek: Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
Anna M. Lasica: Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland
Danuta Mizgalska: Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
Magdalena Nowak: Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
Anna Jacula: Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
Monika Bzowska: Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland
Carsten Scavenius: Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, Aarhus University, Åarhus, Denmark
Jan J. Enghild: Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, Aarhus University, Åarhus, Denmark
Joseph Aduse-Opoku: Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom
Michael A. Curtis: Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom
F. Xavier Gomis-Rüth: Proteolysis Lab, Department of Structural Biology, Molecular Biology Institute of Barcelona, Higher Scientific Research Council (CSIC), Barcelona, Catalonia, Spain
Jan Potempa: ORCiD; Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland

DOI: https://doi.org/10.1128/mBio.02262-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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Bacteria have evolved multiple systems to transport effector proteins to their surface or into the surrounding milieu. These proteins have a wide range of functions, including attachment, motility, nutrient acquisition, and toxicity in the host. Porphyromonas gingivalis

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal