Nature Communications (Feb 2021)
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections
- Alan Bénard,
- Anne Jacobsen,
- Maximilian Brunner,
- Christian Krautz,
- Bettina Klösch,
- Izabela Swierzy,
- Elisabeth Naschberger,
- Malgorzata J. Podolska,
- Dina Kouhestani,
- Paul David,
- Torsten Birkholz,
- Ixchel Castellanos,
- Denis Trufa,
- Horia Sirbu,
- Marcel Vetter,
- Andreas E. Kremer,
- Kai Hildner,
- Andreas Hecker,
- Fabian Edinger,
- Matthias Tenbusch,
- Petra Mühl-Zürbes,
- Alexander Steinkasserer,
- Enrico Richter,
- Hendrik Streeck,
- Marc M. Berger,
- Thorsten Brenner,
- Markus A. Weigand,
- Filip K. Swirski,
- Georg Schett,
- Robert Grützmann,
- Georg F. Weber
Affiliations
- Alan Bénard
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Anne Jacobsen
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Maximilian Brunner
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Christian Krautz
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Bettina Klösch
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Izabela Swierzy
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Elisabeth Naschberger
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Malgorzata J. Podolska
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Dina Kouhestani
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Paul David
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Torsten Birkholz
- Department of Anesthesiology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Ixchel Castellanos
- Department of Anesthesiology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Denis Trufa
- Department of Thoracic Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Horia Sirbu
- Department of Thoracic Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Marcel Vetter
- Department of Internal Medicine 1 - Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Andreas E. Kremer
- Department of Internal Medicine 1 - Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Kai Hildner
- Department of Internal Medicine 1 - Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Andreas Hecker
- Department of Surgery, University Hospital
- Fabian Edinger
- Department of Surgery, University Hospital
- Matthias Tenbusch
- Institute of Clinical and Molecular Virology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Petra Mühl-Zürbes
- Department of Immune Modulation, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Alexander Steinkasserer
- Department of Immune Modulation, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Enrico Richter
- Institute of Virology, University Hospital
- Hendrik Streeck
- Institute of Virology, University Hospital
- Marc M. Berger
- Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen
- Thorsten Brenner
- Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen
- Markus A. Weigand
- Department of Anesthesiology, Heidelberg University Hospital
- Filip K. Swirski
- Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School
- Georg Schett
- Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Robert Grützmann
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- Georg F. Weber
- Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen
- DOI
- https://doi.org/10.1038/s41467-021-21310-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
Here, the authors identify interleukin-3 as a predictive marker for severity and outcome of SARS-CoV-2 infection in a multi-center, prospective study and find that patients with severe COVID-19 have reduced circulating plasmacytoid dendritic cell levels compared to non-severe COVID-19 patients.
