Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

Muhammad Myn Uddin; Izumi Ohigashi; Ryo Motosugi; Tomomi Nakayama; Mie Sakata; Jun Hamazaki; Yasumasa Nishito; Immanuel Rode; Keiji Tanaka; Tatsuya Takemoto; Shigeo Murata; Yousuke Takahama

doi:10.1038/ncomms14419

Nature Communications (Feb 2017)

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

Muhammad Myn Uddin,
Izumi Ohigashi,
Ryo Motosugi,
Tomomi Nakayama,
Mie Sakata,
Jun Hamazaki,
Yasumasa Nishito,
Immanuel Rode,
Keiji Tanaka,
Tatsuya Takemoto,
Shigeo Murata,
Yousuke Takahama

Affiliations

Muhammad Myn Uddin: Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima
Izumi Ohigashi: Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima
Ryo Motosugi: Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo
Tomomi Nakayama: Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo
Mie Sakata: Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima
Jun Hamazaki: Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo
Yasumasa Nishito: Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science
Immanuel Rode: Division of Cellular Immunology, German Cancer Research Center
Keiji Tanaka: Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science
Tatsuya Takemoto: Laboratory for Embryology, Institute of Advanced Medical Sciences, University of Tokushima
Shigeo Murata: Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo
Yousuke Takahama: Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima

DOI: https://doi.org/10.1038/ncomms14419
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

Read online

Foxn1 is involved in thymic epithelial cell (TEC) and CD8+T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal