Reconstitution of microtubule into GTP-responsive nanocapsules

Noriyuki Uchida; Ai Kohata; Kou Okuro; Annalisa Cardellini; Chiara Lionello; Eric A. Zizzi; Marco A. Deriu; Giovanni M. Pavan; Michio Tomishige; Takaaki Hikima; Takuzo Aida

doi:10.1038/s41467-022-33156-5

Nature Communications (Sep 2022)

Reconstitution of microtubule into GTP-responsive nanocapsules

Noriyuki Uchida,
Ai Kohata,
Kou Okuro,
Annalisa Cardellini,
Chiara Lionello,
Eric A. Zizzi,
Marco A. Deriu,
Giovanni M. Pavan,
Michio Tomishige,
Takaaki Hikima,
Takuzo Aida

Affiliations

Noriyuki Uchida: RIKEN Center for Emergent Matter Science
Ai Kohata: Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
Kou Okuro: Department of Chemistry, The University of Hong Kong
Annalisa Cardellini: Department of Applied Science and Technology, Politecnico di Torino
Chiara Lionello: Department of Applied Science and Technology, Politecnico di Torino
Eric A. Zizzi: PolitoBIOMedLab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino
Marco A. Deriu: PolitoBIOMedLab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino
Giovanni M. Pavan: Department of Applied Science and Technology, Politecnico di Torino
Michio Tomishige: Department of Physical Sciences, Aoyama Gakuin University
Takaaki Hikima: RIKEN SPring-8 Center
Takuzo Aida: RIKEN Center for Emergent Matter Science

DOI: https://doi.org/10.1038/s41467-022-33156-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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GTP-triggered release from drug carriers has huge potential in cancer therapy but current carriers suffers from off target release due to ATP also acting as a trigger. Here, the authors report on the development of a microtubule capsule which is engineered to be responsive to only GTP not ATP and demonstrate targeted drug delivery.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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