Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations

• Lukasz Szatkowski,
• Melissa L. Lynn,
• Teryn Holeman,
• Michael R. Williams,
• Anthony P. Baldo,
• Jil C. Tardiff,
• Steven D. Schwartz

Affiliations

Lukasz Szatkowski

Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States

Melissa L. Lynn

§Department of Medicine, University of Arizona, Tucson, Arizona, United States

Teryn Holeman

‡Department of Physiological Sciences, University of Arizona, Tucson, Arizona, United States

Michael R. Williams

Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States

Anthony P. Baldo

Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States

Jil C. Tardiff

‡Department of Physiological Sciences, University of Arizona, Tucson, Arizona, United States

Steven D. Schwartz

Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States