CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules

Xiaodan Wang; Delan Gao; Mingji Li; Hongji Li; Cuiping Li; Xiaoguo Wu; Baohe Yang

doi:10.1038/s41598-017-07646-2

Scientific Reports (Aug 2017)

CVD graphene as an electrochemical sensing platform for simultaneous detection of biomolecules

Xiaodan Wang,
Delan Gao,
Mingji Li,
Hongji Li,
Cuiping Li,
Xiaoguo Wu,
Baohe Yang

Affiliations

Xiaodan Wang: Tianjin Key Laboratory of Film Electronic and Communicate Devices, School of Electrical and Electronic Engineering, Tianjin University of Technology
Delan Gao: Tianjin Key Laboratory of Film Electronic and Communicate Devices, School of Electrical and Electronic Engineering, Tianjin University of Technology
Mingji Li: Tianjin Key Laboratory of Film Electronic and Communicate Devices, School of Electrical and Electronic Engineering, Tianjin University of Technology
Hongji Li: Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology
Cuiping Li: Tianjin Key Laboratory of Film Electronic and Communicate Devices, School of Electrical and Electronic Engineering, Tianjin University of Technology
Xiaoguo Wu: Tianjin Key Laboratory of Film Electronic and Communicate Devices, School of Electrical and Electronic Engineering, Tianjin University of Technology
Baohe Yang: Tianjin Key Laboratory of Film Electronic and Communicate Devices, School of Electrical and Electronic Engineering, Tianjin University of Technology

DOI: https://doi.org/10.1038/s41598-017-07646-2
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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Abstract The development of electrochemical biosensors for the simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA), tryptophan (Trp), and nitrite ( $${{\rm{NO}}}_{2}^{-}$$ NO 2 − ) in human serum is reported in this work. Free-standing graphene nanosheets were fabricated on Ta wire using the chemical vapor deposition (CVD) method. CVD graphene, which here served as a sensing platform, provided a highly sensitive and selective option, with detection limits of AA, DA, UA, Trp, and $${{\rm{NO}}}_{2}^{-}$$ NO 2 − of 1.58, 0.06, 0.09, 0.10, and 6.45 μM (S/N = 3), respectively. The high selectivity of the electrode is here explained by a relationship between the bandgap energy of analyte and the Fermi level of graphene. The high sensitivity in the oxidation current was determined by analyzing the influence of the high surface area and chemical structure of free-standing graphene nanosheets on analyte adsorption capacity. This finding strongly indicates that the CVD graphene electrode can be used as a biosensor to detect five analytes in human serum.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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