RNA-sequencing data highlighting the time-of-day-dependent transcriptome of the central circadian pacemaker in Sox2-deficient mice

Abstract

SOX2 is a stem cell-associated pluripotency transcription factor whose role in neuronal populations is undefined. Here we present the RNA-sequencing based transcriptome profiles of control (Sox2fl/fl) and SOX2 conditional knock-out (Vgat-cre;Sox2fl/fl) mice at four time points in one 24-h circadian cycle. The raw sequencing data were deposited to ArrayExpress database at EMBL-EBI (https://www.ebi.ac.uk/arrayexpress) under the accession number E-MTAB-7496. Results of rhythmicity analysis, differential expression analysis, network prediction, and potential target identification stemming from the RNA-sequencing dataset are also given in this article. The interpretation and discussion of these data can be found in the related research article entitled “SOX2-dependent transcription in clock neurons promotes the robustness of the central circadian pacemaker.” Cheng et al. 2019. Keywords: Transcriptomics, Circadian rhythms, SOX2, Suprachiasmatic nucleus, Mice