Nature Communications (Mar 2023)
Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology
- Fangyun Tian,
- Laura D. Lewis,
- David W. Zhou,
- Gustavo A. Balanza,
- Angelique C. Paulk,
- Rina Zelmann,
- Noam Peled,
- Daniel Soper,
- Laura A. Santa Cruz Mercado,
- Robert A. Peterfreund,
- Linda S. Aglio,
- Emad N. Eskandar,
- G. Rees Cosgrove,
- Ziv M. Williams,
- R. Mark Richardson,
- Emery N. Brown,
- Oluwaseun Akeju,
- Sydney S. Cash,
- Patrick L. Purdon
Affiliations
- Fangyun Tian
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
- Laura D. Lewis
- Department of Biomedical Engineering, Boston University
- David W. Zhou
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
- Gustavo A. Balanza
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
- Angelique C. Paulk
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Rina Zelmann
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Noam Peled
- Department of Radiology, MGH/HST Martinos Center for Biomedical Imaging and Harvard Medical School
- Daniel Soper
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Laura A. Santa Cruz Mercado
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
- Robert A. Peterfreund
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
- Linda S. Aglio
- Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital
- Emad N. Eskandar
- Department of Neurological Surgery, Albert Einstein College of Medicine
- G. Rees Cosgrove
- Department of Neurosurgery, Brigham and Women’s Hospital
- Ziv M. Williams
- Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School
- R. Mark Richardson
- Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School
- Emery N. Brown
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
- Oluwaseun Akeju
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
- Sydney S. Cash
- Department of Neurology, Massachusetts General Hospital, Harvard Medical School
- Patrick L. Purdon
- Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-023-37463-3
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
The neural mechanisms underpinning ketamine’s dissociative and antidepressant effects remain poorly understood. Here, the authors analyzed ketamine-induced brain dynamics with intracranial recordings in humans and found that ketamine engages different brain areas in distinct frequency-dependent patterns that may relate to its dissociative and antidepressant effects.
