Drug Induced Hepatotoxicity in Targeted Therapy for Lung Cancer

Abstract

Targeted drugs aimed at driver gene, such as Gefitinib, Erlotinib and Crizotinib, have an irreplaceable position in the therapy of advanced non-small cell lung cancer. These drugs bring benefit to patients, however, higher hepatotoxicity is also presented. Now, drug induced hepatotoxicity and its mechanism are reviewed.

Keywords

• Lung neoplasms
• Targeted drugs
• Hepatotoxicity