BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

John Maringa Githaka; Namita Tripathi; Raven Kirschenman; Namrata Patel; Vrajesh Pandya; David A. Kramer; Rachel Montpetit; Lin Fu Zhu; Nahum Sonenberg; Richard P. Fahlman; Nika N. Danial; D. Alan Underhill; Ing Swie Goping

doi:10.1038/s41467-021-23269-8

Nature Communications (May 2021)

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

John Maringa Githaka,
Namita Tripathi,
Raven Kirschenman,
Namrata Patel,
Vrajesh Pandya,
David A. Kramer,
Rachel Montpetit,
Lin Fu Zhu,
Nahum Sonenberg,
Richard P. Fahlman,
Nika N. Danial,
D. Alan Underhill,
Ing Swie Goping

Affiliations

John Maringa Githaka: Department of Biochemistry, University of Alberta
Namita Tripathi: Department of Biochemistry, University of Alberta
Raven Kirschenman: Department of Biochemistry, University of Alberta
Namrata Patel: Department of Biochemistry, University of Alberta
Vrajesh Pandya: Department of Biochemistry, University of Alberta
David A. Kramer: Department of Biochemistry, University of Alberta
Rachel Montpetit: Department of Biochemistry, University of Alberta
Lin Fu Zhu: Department of Surgery, University of Alberta
Nahum Sonenberg: Department of Biochemistry, McGill University
Richard P. Fahlman: Department of Biochemistry, University of Alberta
Nika N. Danial: Department of Cancer Biology, Dana-Farber Cancer Institute
D. Alan Underhill: Department of Oncology, University of Alberta
Ing Swie Goping: Department of Biochemistry, University of Alberta

DOI: https://doi.org/10.1038/s41467-021-23269-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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