Nature Communications (Jan 2016)

Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex

  • Daisuke Morita,
  • Yukie Yamamoto,
  • Tatsuaki Mizutani,
  • Takeshi Ishikawa,
  • Juri Suzuki,
  • Tatsuhiko Igarashi,
  • Naoki Mori,
  • Takashi Shiina,
  • Hidetoshi Inoko,
  • Hiroaki Fujita,
  • Kazuhiro Iwai,
  • Yoshimasa Tanaka,
  • Bunzo Mikami,
  • Masahiko Sugita

DOI
https://doi.org/10.1038/ncomms10356
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Lipid antigens have been added to the antigenic repertoire in recent years. Here, the authors have identified Mamu-B*098 as a lipopeptide antigen presenting molecule and using structural and biochemical analysis have shown that it has a different antigen binding pocket to previously analysed proteins.