Nature Communications (Apr 2016)
Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin
- Kyoko Hiragami-Hamada,
- Szabolcs Soeroes,
- Miroslav Nikolov,
- Bryan Wilkins,
- Sarah Kreuz,
- Carol Chen,
- Inti A. De La Rosa-Velázquez,
- Hans Michael Zenn,
- Nils Kost,
- Wiebke Pohl,
- Aleksandar Chernev,
- Dirk Schwarzer,
- Thomas Jenuwein,
- Matthew Lorincz,
- Bastian Zimmermann,
- Peter Jomo Walla,
- Heinz Neumann,
- Tuncay Baubec,
- Henning Urlaub,
- Wolfgang Fischle
Affiliations
- Kyoko Hiragami-Hamada
- Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry
- Szabolcs Soeroes
- Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry
- Miroslav Nikolov
- Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry
- Bryan Wilkins
- Applied Synthetic Biology, Institute for Microbiology and Genetics, Georg-August University Göttingen
- Sarah Kreuz
- Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry
- Carol Chen
- Department of Medical Genetics, Life Sciences Institute, The University of British Columbia
- Inti A. De La Rosa-Velázquez
- Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics
- Hans Michael Zenn
- Biaffin GmbH & Co KG
- Nils Kost
- Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry
- Wiebke Pohl
- Biomolecular Spectroscopy and Single-Molecule Detection, Max Planck Institute for Biophysical Chemistry
- Aleksandar Chernev
- Bioanalytical Mass Spectrometry, Max Planck Institute for Biophysical Chemistry
- Dirk Schwarzer
- Interfaculty Institute of Biochemistry, University of Tübingen
- Thomas Jenuwein
- Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics
- Matthew Lorincz
- Department of Medical Genetics, Life Sciences Institute, The University of British Columbia
- Bastian Zimmermann
- Biaffin GmbH & Co KG
- Peter Jomo Walla
- Biomolecular Spectroscopy and Single-Molecule Detection, Max Planck Institute for Biophysical Chemistry
- Heinz Neumann
- Applied Synthetic Biology, Institute for Microbiology and Genetics, Georg-August University Göttingen
- Tuncay Baubec
- Department of Molecular Mechanisms of Disease, University of Zürich
- Henning Urlaub
- Bioanalytical Mass Spectrometry, Max Planck Institute for Biophysical Chemistry
- Wolfgang Fischle
- Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry
- DOI
- https://doi.org/10.1038/ncomms11310
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Heterochromatin protein 1 (HP1), including HP1 α, β and γ, is a family of non-histone chromatin factors thought to be involved in chromatin organization. Here, the authors show that dimeric HP1β interacts dynamically with H3K9me3, a hallmark of heterochromatin, and bridges condensed chromatin.
