Transplantation Direct (Oct 2017)

Prolonged Delayed Renal Graft Function Secondary to Venous Hypertension

  • Suraj Mishra, BA,
  • Gaurav Gupta, MD,
  • I. Moinuddin, MD,
  • Brian Strife, MD,
  • Uma Prasad, MD,
  • D. Massey, MD, PhD,
  • Anne King, MD,
  • Dhiren Kumar, MD,
  • Chandra S. Bhati, MD

DOI
https://doi.org/10.1097/TXD.0000000000000726
Journal volume & issue
Vol. 3, no. 10
p. e214

Abstract

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Abstract. The case of a 39-year-old highly sensitized woman who underwent second renal transplantation after being on warfarin because of a history of frequent thromboses of her left femoral arteriovenous graft (AVG) is reported here. The patient received a flow cytometric positive crossmatch kidney transplant from a deceased donor. Her posttransplant course was complicated by prolonged delayed graft function (DGF) lasting for 9 months. Antibody-mediated rejection occurred in the immediate postoperative period. This resolved after treatment, and resolution was confirmed by repeat biopsy. Despite this, she had persistent DGF and remained dialysis dependent. A computed tomography scan due to the development of perinephric hematoma after posttransplant biopsy demonstrated venous collateralization around the allograft. At 7 months posttransplant, a venogram during declotting of AVG revealed chronic thrombus in the inferior vena cava (IVC) above the level of native renal veins with a venous gradient of 26 mmHg. After declotting of the graft, iliac venoplasty, and subsequent IVC stent, her renal function continues to improve with a most recent creatinine of 1.4 mg/dL at 36 months posttransplant. Venous hypertension secondary to IVC thrombosis in presence of patent femoral AVG should be considered as a rare cause of prolonged DGF.