Nature Communications (Oct 2018)
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
- Christoffer Clemmensen,
- Sigrid Jall,
- Maximilian Kleinert,
- Carmelo Quarta,
- Tim Gruber,
- Josefine Reber,
- Stephan Sachs,
- Katrin Fischer,
- Annette Feuchtinger,
- Angelos Karlas,
- Stephanie E. Simonds,
- Gerald Grandl,
- Daniela Loher,
- Eva Sanchez-Quant,
- Susanne Keipert,
- Martin Jastroch,
- Susanna M. Hofmann,
- Emmani B. M. Nascimento,
- Patrick Schrauwen,
- Vasilis Ntziachristos,
- Michael A. Cowley,
- Brian Finan,
- Timo D. Müller,
- Matthias H. Tschöp
Affiliations
- Christoffer Clemmensen
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Sigrid Jall
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Maximilian Kleinert
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Carmelo Quarta
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Tim Gruber
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Josefine Reber
- Institute of Biological and Medical Imaging, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)
- Stephan Sachs
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Katrin Fischer
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Annette Feuchtinger
- Research Unit Analytical Pathology, Helmholtz Zentrum München
- Angelos Karlas
- Institute of Biological and Medical Imaging, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)
- Stephanie E. Simonds
- Department of Physiology, and Biomedicine Discovery Institute, Monash University
- Gerald Grandl
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Daniela Loher
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Eva Sanchez-Quant
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Susanne Keipert
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Martin Jastroch
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Susanna M. Hofmann
- Institute of Diabetes and Regeneration Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH)
- Emmani B. M. Nascimento
- Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
- Patrick Schrauwen
- Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center
- Vasilis Ntziachristos
- Institute of Biological and Medical Imaging, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)
- Michael A. Cowley
- Department of Physiology, and Biomedicine Discovery Institute, Monash University
- Brian Finan
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Timo D. Müller
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- Matthias H. Tschöp
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)
- DOI
- https://doi.org/10.1038/s41467-018-06769-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena through small-molecule combination therapy, and show that this treatment improves metabolic health of obese mice.
