Sphingolipid-dependent Dscam sorting regulates axon segregation

Gaurav Goyal; Junfeng Zheng; Elisabeth Adam; Georg Steffes; Mamta Jain; Kristaps Klavins; Thomas Hummel

doi:10.1038/s41467-019-08765-2

Nature Communications (Feb 2019)

Sphingolipid-dependent Dscam sorting regulates axon segregation

Gaurav Goyal,
Junfeng Zheng,
Elisabeth Adam,
Georg Steffes,
Mamta Jain,
Kristaps Klavins,
Thomas Hummel

Affiliations

Gaurav Goyal: Department for Neurobiology, University of Vienna
Junfeng Zheng: Institut für Neuro- und Verhaltensbiologie, Universität Münster
Elisabeth Adam: Department for Neurobiology, University of Vienna
Georg Steffes: Institut für Neuro- und Verhaltensbiologie, Universität Münster
Mamta Jain: Division of Cell and Developmental Biology, Centre for Anatomy and Cell Biology, Medical University of Vienna
Kristaps Klavins: CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences
Thomas Hummel: Department for Neurobiology, University of Vienna

DOI: https://doi.org/10.1038/s41467-019-08765-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosophila Mushroom Bodies

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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