Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE)

Yanyan Kong; Yanyan Kong; Fushuai Wang; Jiao Wang; Cuiping Liu; Yinping Zhou; Zhengqin Xu; Chencheng Zhang; Bomin Sun; Yihui Guan

doi:10.3389/fnagi.2020.00217

Frontiers in Aging Neuroscience (Jul 2020)

Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE)

Yanyan Kong,
Yanyan Kong,
Fushuai Wang,
Jiao Wang,
Cuiping Liu,
Yinping Zhou,
Zhengqin Xu,
Chencheng Zhang,
Bomin Sun,
Yihui Guan

Affiliations

Yanyan Kong: Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yanyan Kong: PET Center, Huashan Hospital, Fudan University, Shanghai, China
Fushuai Wang: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China
Jiao Wang: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China
Cuiping Liu: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China
Yinping Zhou: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China
Zhengqin Xu: Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China
Chencheng Zhang: Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Bomin Sun: Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yihui Guan: PET Center, Huashan Hospital, Fudan University, Shanghai, China

DOI: https://doi.org/10.3389/fnagi.2020.00217
Journal volume & issue: Vol. 12

Abstract

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Diabetes and Alzheimer’s disease (AD) place a significant burden on health care systems in the world and its aging populations. These diseases have long been regarded as separate entities; however, advanced glycation end products (AGEs) and the receptors for AGEs (RAGE) may be a link between diabetes and AD. In our study, mice injected with AGEs through stereotaxic surgery showed significant AD-like features: behavior showed decreased memory; immunofluorescence showed increased phosphorylated tau and APP. These results suggest links between diabetes and AD. Patients with diabetes are at a higher risk of developing AD, and the possible underlying molecular components of this association are now beginning to emerge.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

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