Synthesis and Structure of Novel Phenothiazine Derivatives, and Compound Prioritization via In Silico Target Search and Screening for Cytotoxic and Cholinesterase Modulatory Activities in Liver Cancer Cells and In Vivo in Zebrafish

• Mehmet Murat Kisla,
• Murat Yaman,
• Fikriye Zengin-Karadayi,
• Busra Korkmaz,
• Omer Bayazeid,
• Amrish Kumar,
• Ravindra Peravali,
• Damla Gunes,
• Rafed Said Tiryaki,
• Emine Gelinci,
• Gulcin Cakan-Akdogan,
• Zeynep Ates-Alagoz,
• Ozlen Konu

Affiliations

Mehmet Murat Kisla

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey

Murat Yaman

Interdisciplinary Program in Neuroscience, Bilkent University, Ankara, Turkey

Fikriye Zengin-Karadayi

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey

Busra Korkmaz

Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

Omer Bayazeid

Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

Amrish Kumar

Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany

Ravindra Peravali

Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany

Damla Gunes

Interdisciplinary Program in Neuroscience, Bilkent University, Ankara, Turkey

Rafed Said Tiryaki

Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey

Emine Gelinci

Izmir Biomedicine and Genome Center (IBG), Izmir, Turkey

Gulcin Cakan-Akdogan

Izmir Biomedicine and Genome Center (IBG), Izmir, Turkey

Zeynep Ates-Alagoz

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey

Ozlen Konu

Interdisciplinary Program in Neuroscience, Bilkent University, Ankara, Turkey