Ultrasound promoted green synthesis of benzofuran substituted thiazolo[3,2-b][1,2,4]triazoles

Abstract

A highly efficient, eco-friendly and one-pot synthesis of benzofuran substituted thiazolo[3,2-b][1,2,4]triazoles was developed involving the reaction of 2-acetyl benzofurans and 5-mercapto-3-(4-chlorophenyl)-1,2,4triazole in the presence of molecular iodine under ultrasonic conditions to give 5-(benzofuran-2-yl)-acylthio-3-(4-chlorophenyl)-1,2,4triazoles, which was further cyclised using Eaton’s reagent under microwave conditions to give 5-(benzofuran-2-yl)-2-(4-chlorophenyl)thiazolo[3,2-b][1,2,4]triazoles.

Keywords

• 5-(benzofuran-2-yl)-2-(4-chlorophenyl)thiazolo[3,2-b][1,2,4]triazoles
• 5-(benzofuran-2-yl)-acylthio-3-(4-chlorophenyl)-1,2,4triazoles
• 5-mercapto-3-(4-chlorophenyl)-1,2,4triazole
• microwave conditions
• ultrasonic conditions