Preoperatively administered single dose of dexketoprofen decreases pain intensity on the first 5 days after craniotomy: A single-centre placebo-controlled, randomized trial

Simon Éva; Csipkés Csaba; Andráskó Dániel; Kovács Veronika; Szabó-Maák Zoltán; Tankó Béla; Buchholcz Gyula; Fülesdi Béla; Molnár Csilla

doi:10.1515/tnsci-2022-0323

Translational Neuroscience (Dec 2023)

Preoperatively administered single dose of dexketoprofen decreases pain intensity on the first 5 days after craniotomy: A single-centre placebo-controlled, randomized trial

Simon Éva,
Csipkés Csaba,
Andráskó Dániel,
Kovács Veronika,
Szabó-Maák Zoltán,
Tankó Béla,
Buchholcz Gyula,
Fülesdi Béla,
Molnár Csilla

Affiliations

Simon Éva: Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Csipkés Csaba: Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Andráskó Dániel: Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Kovács Veronika: Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Szabó-Maák Zoltán: Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Tankó Béla: Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Buchholcz Gyula: University Pharmacy, Clinical Centre, University of Debrecen, Debrecen, Hungary
Fülesdi Béla: Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Molnár Csilla: Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

DOI: https://doi.org/10.1515/tnsci-2022-0323
Journal volume & issue: Vol. 14, no. 1
pp. p. 1 – 211

Abstract

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Headache attributed to craniotomy is an underestimated and under-treated condition. Previous studies confirmed the efficacy of preemptive analgesia with non-steroidal anti-inflammatory agents. The aim of the present work was to test the hypothesis of whether a single preoperatively administered dose of dexketoprofen (DEX) has the potency to decrease postcraniotomy headache (PCH) as compared to placebo (PL).

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

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