Einstein (São Paulo) (May 2022)

Relation between red blood cell distribution width and acute kidney injury in patients with sepsis

  • Marina Larissa Vettorello Ramires,
  • Manoela Fidelis Batista Leite,
  • Daniel Zu Yow Lo,
  • Leonardo Bonilla da Silveira,
  • Leonardo José Rolim Ferraz,
  • Andreia Pardini,
  • Araci Massami Sakashita,
  • Andrea Tiemi Kondo,
  • Guilherme Benfatti Olivato,
  • Marcelino de Souza Durão Junior,
  • Adelson Marçal Rodrigues,
  • Daniela Mendes Chiloff,
  • Danilo Candido de Almeida,
  • Miguel Angelo Goes

DOI
https://doi.org/10.31744/einstein_journal/2022ao6828
Journal volume & issue
Vol. 20

Abstract

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ABSTRACT Objective The objective of the present study is to evaluate the association of red blood cell distribution width with acute kidney injury in sepsis. Methods This is a retrospective study of 849 critically ill patients with sepsis in intensive care unit. Demographic data, renal function, inflammation, complete blood count, and acid-base parameters were compared between acute kidney injury and non-acute kidney injury groups. Therefore, a multivariate analysis was performed to observe independent predictive factors. Results Comparatively, higher levels of C-reactive protein, lactate, red blood cell distribution width, and Simplified Acute Physiology Score 3 were found in the acute kidney injury group. The study showed a higher frequency of women, hemoglobin (Hgb) concentration, platelets, bicarbonate and PaO2/FiO2 ratio in the non-acute kidney injury group. In addition, there was an independent association of comorbidity-chronic kidney disease [OR 3.549, 95%CI: 1.627-7.743; p<0.001], urea [OR 1.047, 95%CI: 1.036-1.058; p<0.001] and RDW [OR 1.158, 95%CI: 1.045-1.283; p=0.005] with acute kidney injury in sepsis patients. Conclusion As an elective risk factor, red blood cell distribution width was independently associated with sepsis-related acute kidney injury. Thus, red blood cell distribution width acts like a predictive factor for sepsis-induced acute kidney injury in intensive care unit admission.

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