NEGATIVE PRESSURE THERAPY IN COMPLEX PROGRAM FOR TREATMENT OF PANCREATOGENIC SEPSIS

Abstract

Objectives Critical analysis of the own first clinical results of the treatment in patients with pancreatogenic sepsis by inclusion of alternating negative pressure inOBJECTIVES. Critical analysis of the own first clinical results of the treatment in patients with pancreatogenic sepsis by inclusion of alternating negative pressure into the complex therapy with assessing the possibility of using NPWT as an alternative to traditional omentobursostomy.METHODS. We report the literature data and own first clinical experience in treating patients with pancreatogenic sepsis by negative variable pressure.RESULTS. The advantages of the negative variable pressure method are earlier arrest of systemic inflammatory response syndrome, continuous evacuation of exudate, effective cleansing of the wound cavity, stimulation of granulation tissue proliferation, reducing the risk of compartment syndrome, shortening of hospital stay in patients with a favorable outcome and improved quality of life in patients during their stay in hospital. The disadvantages of NPWT should include development of petechial and arrosive bleeding in 12.5%, the occurrence of intestinal fistulas in 12.5% of clinical observations.CONCLUSION. Today, it is not clear what place will NPWT take in the treatment of pancreatogenic sepsis. The data obtained in the course of literature search and analysis of our own clinical experience using the method of negative pressure therapy, indicate the need to confirm the initial clinical results in further comparative randomized controlled trials.to the complex therapy with assessing the possibility of using NPWT as an alternative to traditional omentobursostomy. Methods We report the literature data and own first clinical experience in treating patients with pancreatogenic sepsis by negative variable pressure. Results The advantages of the negative variable pressure method are earlier arrest of systemic inflammatory response syndrome, continuous evacuation of exudate, effective cleansing of the wound cavity, stimulation of granulation tissue proliferation, reducing the risk of compartment syndrome, shortening of hospital stay in patients with a favorable outcome and improved quality of life in patients during their stay in hospital. The disadvantages of NPWT should include development of petechial and arrosive bleeding in 12.5%, the occurrence of intestinal fistulas in 12.5% of clinical observations. Conclusion Today, it is not clear what place will NPWT take in the treatment of pancreatogenic sepsis. The data obtained in the course of literature search and analysis of our own clinical experience using the method of negative pressure therapy, indicate the need to confirm the initial clinical results in further comparative randomized controlled trials.

Keywords

• infected pancreatic necrosis
• negative pressure method
• npwt
• pancreatogenic sepsis
• surgical treatment