Lysyl oxidase-like 2 processing by factor Xa modulates its activity and substrate preference

Huilei Wang; Alan Poe; Marta Martinez Yus; Lydia Pak; Kavitha Nandakumar; Lakshmi Santhanam

doi:10.1038/s42003-023-04748-8

Communications Biology (Apr 2023)

Lysyl oxidase-like 2 processing by factor Xa modulates its activity and substrate preference

Huilei Wang,
Alan Poe,
Marta Martinez Yus,
Lydia Pak,
Kavitha Nandakumar,
Lakshmi Santhanam

Affiliations

Huilei Wang: Department of Biomedical Engineering, Johns Hopkins University School of Medicine
Alan Poe: Department of Biomedical Engineering, Johns Hopkins University School of Medicine
Marta Martinez Yus: Department of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering
Lydia Pak: Department of Biomedical Engineering, Johns Hopkins University School of Medicine
Kavitha Nandakumar: Department of Anesthesiology and CCM, Johns Hopkins University School of Medicine
Lakshmi Santhanam: Department of Biomedical Engineering, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s42003-023-04748-8
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

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A role for Factor Xa in the proteolytic processing of LOXL2 is identified and the resulting processed LOXL2 changes affinity from collagen IV to collagen I and increasingly binds to LOX, suggesting that LOX could be recruited to the regions where cleaved LOXL2 is deposited.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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