In Vivo Positive Magnetic Resonance Imaging of Brain Cancer (U87MG) Using Folic Acid-Conjugated Polyacrylic Acid-Coated Ultrasmall Manganese Oxide Nanoparticles

Shanti Marasini; Huan Yue; Son-Long Ho; Ji-Ae Park; Soyeon Kim; Ji-Ung Yang; Hyunsil Cha; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Abdullah Khamis Ali Al Saidi; Dejun Zhao; Ying Liu; Kwon-Seok Chae; Yongmin Chang; Gang-Ho Lee

doi:10.3390/app11062596

Applied Sciences (Mar 2021)

In Vivo Positive Magnetic Resonance Imaging of Brain Cancer (U87MG) Using Folic Acid-Conjugated Polyacrylic Acid-Coated Ultrasmall Manganese Oxide Nanoparticles

Shanti Marasini,
Huan Yue,
Son-Long Ho,
Ji-Ae Park,
Soyeon Kim,
Ji-Ung Yang,
Hyunsil Cha,
Shuwen Liu,
Tirusew Tegafaw,
Mohammad Yaseen Ahmad,
Abdullah Khamis Ali Al Saidi,
Dejun Zhao,
Ying Liu,
Kwon-Seok Chae,
Yongmin Chang,
Gang-Ho Lee

Affiliations

Shanti Marasini: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Huan Yue: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Son-Long Ho: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Ji-Ae Park: Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, Korea
Soyeon Kim: Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, Korea
Ji-Ung Yang: Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, Korea
Hyunsil Cha: Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Korea
Shuwen Liu: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Tirusew Tegafaw: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Mohammad Yaseen Ahmad: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Abdullah Khamis Ali Al Saidi: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Dejun Zhao: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Ying Liu: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea
Kwon-Seok Chae: Department of Biology Education, Teachers’ College, Kyungpook National University, Taegu 41566, Korea
Yongmin Chang: Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Korea
Gang-Ho Lee: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea

DOI: https://doi.org/10.3390/app11062596
Journal volume & issue: Vol. 11, no. 6
p. 2596

Abstract

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Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r1) value of 9.3 s−1mM−1 (r2/r1 = 2.2). Their application potential as cancer-targeting T1 magnetic resonance imaging contrast agents was confirmed by their enhanced T1 contrast enhancements at the brain cancer (U87MG) site upon intravenous administration to mice tails.

Published in Applied Sciences

ISSN: 2076-3417 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General); Science: Biology (General); Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/applsci

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