Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation

Yan Xue; Zhenhui Zhong; C. Jake Harris; Javier Gallego-Bartolomé; Ming Wang; Colette Picard; Xueshi Cao; Shan Hua; Ivy Kwok; Suhua Feng; Yasaman Jami-Alahmadi; Jihui Sha; Jason Gardiner; James Wohlschlegel; Steven E. Jacobsen

doi:10.1038/s41467-021-24553-3

Nature Communications (Jul 2021)

Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation

Yan Xue,
Zhenhui Zhong,
C. Jake Harris,
Javier Gallego-Bartolomé,
Ming Wang,
Colette Picard,
Xueshi Cao,
Shan Hua,
Ivy Kwok,
Suhua Feng,
Yasaman Jami-Alahmadi,
Jihui Sha,
Jason Gardiner,
James Wohlschlegel,
Steven E. Jacobsen

Affiliations

Yan Xue: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Zhenhui Zhong: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
C. Jake Harris: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Javier Gallego-Bartolomé: Instituto de Biología Molecular y Celular de Plantas (IBMCP), CSIC‐Universidad Politécnica de Valencia
Ming Wang: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Colette Picard: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Xueshi Cao: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Shan Hua: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Ivy Kwok: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Suhua Feng: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Yasaman Jami-Alahmadi: Department of Biological Chemistry, UCLA
Jihui Sha: Department of Biological Chemistry, UCLA
Jason Gardiner: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
James Wohlschlegel: Department of Biological Chemistry, UCLA
Steven E. Jacobsen: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles

DOI: https://doi.org/10.1038/s41467-021-24553-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

MORC ATPases are required for transposable element silencing and heterochromatin condensation in plants and animals. Here the authors show that Arabidopsis MORCs colocalize with sites of RNA-directed DNA methylation and provide evidence that they act as molecular tethers to efficiently establish DNA methylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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