Phosphatidylinositolphosphate phosphatase activities and cancer

Simon A. Rudge; Michael J.O. Wakelam

Journal of Lipid Research (Feb 2016)

Phosphatidylinositolphosphate phosphatase activities and cancer

Simon A. Rudge,
Michael J.O. Wakelam

Affiliations

Simon A. Rudge: To whom correspondence should be addressed. (S.A.R.); (M.J.O.W.); To whom correspondence should be addressed. (S.A.R.); (M.J.O.W.); Signalling Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom
Michael J.O. Wakelam: To whom correspondence should be addressed. (S.A.R.); (M.J.O.W.); To whom correspondence should be addressed. (S.A.R.); (M.J.O.W.); Signalling Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom

Journal volume & issue: Vol. 57, no. 2
pp. 176 – 192

Abstract

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Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon their target cells following receptor occupation. Overactivation of these pathways has been implicated in a number of pathologies, in particular a range of malignancies. The tight regulation of signaling pathways necessitates the involvement of both stimulatory and terminating enzymes; inappropriate activation of a pathway can thus result from activation or inhibition of the two signaling arms. The focus of this review is to discuss, in detail, the activities of the identified families of phosphoinositide phosphatase expressed in humans, and how they regulate the levels of phosphoinositides implicated in promoting malignancy.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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