G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination

Hyun-Jeong Yang; Anna Vainshtein; Galia Maik-Rachline; Elior Peles

doi:10.1038/ncomms10884

Nature Communications (Mar 2016)

G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination

Hyun-Jeong Yang,
Anna Vainshtein,
Galia Maik-Rachline,
Elior Peles

Affiliations

Hyun-Jeong Yang: Department of Molecular Cell Biology, Weizmann Institute of Science
Anna Vainshtein: Department of Molecular Cell Biology, Weizmann Institute of Science
Galia Maik-Rachline: Department of Molecular Cell Biology, Weizmann Institute of Science
Elior Peles: Department of Molecular Cell Biology, Weizmann Institute of Science

DOI: https://doi.org/10.1038/ncomms10884
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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The molecular mechanism controlling oligodendrocyte differentiation is not fully understood. Here the authors show that G protein coupled receptor 37 acts as a negative regulator of CNS myelination, and this effect is mediated by suppression of ERK signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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