Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration

Dathe Z. Benissan-Messan; Hua Zhu; Weina Zhong; Tao Tan; Jianjie Ma; Peter H. U. Lee; Peter H. U. Lee; Peter H. U. Lee

doi:10.3389/fphys.2020.583393

Frontiers in Physiology (Nov 2020)

Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration

Dathe Z. Benissan-Messan,
Hua Zhu,
Weina Zhong,
Tao Tan,
Jianjie Ma,
Peter H. U. Lee,
Peter H. U. Lee,
Peter H. U. Lee

Affiliations

Dathe Z. Benissan-Messan: Department of Surgery, The Ohio State University, Columbus, OH, United States
Hua Zhu: Department of Surgery, The Ohio State University, Columbus, OH, United States
Weina Zhong: Department of Surgery, The Ohio State University, Columbus, OH, United States
Tao Tan: Department of Surgery, The Ohio State University, Columbus, OH, United States
Jianjie Ma: Department of Surgery, The Ohio State University, Columbus, OH, United States
Peter H. U. Lee: Department of Surgery, The Ohio State University, Columbus, OH, United States
Peter H. U. Lee: Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States
Peter H. U. Lee: Department of Cardiothoracic Surgery, Southcoast Health, Fall River, MA, United States

DOI: https://doi.org/10.3389/fphys.2020.583393
Journal volume & issue: Vol. 11

Abstract

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Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein’s wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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