Nature Communications (Nov 2018)
Structural insights into the function of type VI secretion system TssA subunits
- Samuel R. Dix,
- Hayley J. Owen,
- Ruyue Sun,
- Asma Ahmad,
- Sravanthi Shastri,
- Helena L. Spiewak,
- Daniel J. Mosby,
- Matthew J. Harris,
- Sarah L. Batters,
- Thomas A. Brooker,
- Svetomir B. Tzokov,
- Svetlana E. Sedelnikova,
- Patrick J. Baker,
- Per A. Bullough,
- David W. Rice,
- Mark S. Thomas
Affiliations
- Samuel R. Dix
- Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield
- Hayley J. Owen
- Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield
- Ruyue Sun
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School
- Asma Ahmad
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School
- Sravanthi Shastri
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School
- Helena L. Spiewak
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School
- Daniel J. Mosby
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School
- Matthew J. Harris
- Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield
- Sarah L. Batters
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School
- Thomas A. Brooker
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School
- Svetomir B. Tzokov
- Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield
- Svetlana E. Sedelnikova
- Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield
- Patrick J. Baker
- Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield
- Per A. Bullough
- Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield
- David W. Rice
- Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield
- Mark S. Thomas
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School
- DOI
- https://doi.org/10.1038/s41467-018-07247-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
TssA is an important component of the bacterial type VI secretion system (T6SS). Here, Dix et al. integrate structural, phylogenetic and functional analysis of the TssA subunits, providing new insights into their role in T6SS assembly and function.
