Nature Communications (Sep 2021)
SPOP mutation induces DNA methylation via stabilizing GLP/G9a
- Jianong Zhang,
- Kun Gao,
- Hongyan Xie,
- Dejie Wang,
- Pingzhao Zhang,
- Ting Wei,
- Yuqian Yan,
- Yunqian Pan,
- Wenbin Ye,
- Huifen Chen,
- Qing Shi,
- Yao Li,
- Shi-min Zhao,
- Xiaonan Hou,
- Saravut J. Weroha,
- Yuzhuo Wang,
- Jun Zhang,
- R. Jeffrey Karnes,
- Housheng Hansen He,
- Liguo Wang,
- Chenji Wang,
- Haojie Huang
Affiliations
- Jianong Zhang
- State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University
- Kun Gao
- Department of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University
- Hongyan Xie
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- Dejie Wang
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- Pingzhao Zhang
- Fudan University Shanghai Cancer Center and Department of Pathology, Shanghai Medical College, Fudan University
- Ting Wei
- Divison of Computational Biology, Mayo Clinic College of Medicine and Science
- Yuqian Yan
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- Yunqian Pan
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- Wenbin Ye
- Department of Automation, Xiamen University
- Huifen Chen
- Department of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University
- Qing Shi
- State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University
- Yao Li
- State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University
- Shi-min Zhao
- State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University
- Xiaonan Hou
- Department of Oncology, Mayo Clinic College of Medicine
- Saravut J. Weroha
- Department of Oncology, Mayo Clinic College of Medicine
- Yuzhuo Wang
- Department of Experimental Therapeutics, BC Cancer Research Centre
- Jun Zhang
- Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science
- R. Jeffrey Karnes
- Department of Urology, Mayo Clinic College of Medicine and Science
- Housheng Hansen He
- Department of Medical Biophysics, University of Toronto
- Liguo Wang
- Divison of Computational Biology, Mayo Clinic College of Medicine and Science
- Chenji Wang
- State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University
- Haojie Huang
- Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science
- DOI
- https://doi.org/10.1038/s41467-021-25951-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prostate cancer cells susceptible to DNA demethylating agents.
