Nature Communications (Dec 2021)
Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
- Friederike L. Pennemann,
- Assel Mussabekova,
- Christian Urban,
- Alexey Stukalov,
- Line Lykke Andersen,
- Vincent Grass,
- Teresa Maria Lavacca,
- Cathleen Holze,
- Lila Oubraham,
- Yasmine Benamrouche,
- Enrico Girardi,
- Rasha E. Boulos,
- Rune Hartmann,
- Giulio Superti-Furga,
- Matthias Habjan,
- Jean-Luc Imler,
- Carine Meignin,
- Andreas Pichlmair
Affiliations
- Friederike L. Pennemann
- Technical University of Munich, School of Medicine, Institute of Virology
- Assel Mussabekova
- Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire
- Christian Urban
- Technical University of Munich, School of Medicine, Institute of Virology
- Alexey Stukalov
- Technical University of Munich, School of Medicine, Institute of Virology
- Line Lykke Andersen
- Technical University of Munich, School of Medicine, Institute of Virology
- Vincent Grass
- Technical University of Munich, School of Medicine, Institute of Virology
- Teresa Maria Lavacca
- Technical University of Munich, School of Medicine, Institute of Virology
- Cathleen Holze
- Innate Immunity Laboratory, Max-Planck Institute of Biochemistry
- Lila Oubraham
- Technical University of Munich, School of Medicine, Institute of Virology
- Yasmine Benamrouche
- Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire
- Enrico Girardi
- CeMM - Center for Molecular Medicine of the Austrian Academy of Sciences
- Rasha E. Boulos
- Computer Science and Mathematics Department, School of Arts and Science, Lebanese American University
- Rune Hartmann
- Aarhus University, Department of Molecular Biology and Genetics - Structural Biology
- Giulio Superti-Furga
- CeMM - Center for Molecular Medicine of the Austrian Academy of Sciences
- Matthias Habjan
- Innate Immunity Laboratory, Max-Planck Institute of Biochemistry
- Jean-Luc Imler
- Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire
- Carine Meignin
- Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire
- Andreas Pichlmair
- Technical University of Munich, School of Medicine, Institute of Virology
- DOI
- https://doi.org/10.1038/s41467-021-27192-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Whether there are conserved nucleic acid (NA) binding proteins across species is not fully known. Using data from human, mouse and fly, the authors identify common binders, implicate TAOKs and show that these kinases bind NAs across species and promote virus defence in mammalian cells.
