A simple method for modeling amyloid kinetics featuring position biased fiber breakage

Abstract

A mathematical model of amyloid fiber formation is described that is able to simply specify different rates of fiber breakage at internal versus end regions. This Note presents the derivation of the relevant equations and provides results showing the dramatic effects of position biased fiber breakage on the kinetics of amyloid growth.

Keywords

• amyloidosis
• fibril fragmentation
• disease mechanisms