Markers of subclinical atherosclerosis in the ten-year risk estimation of cardiovascular events

Abstract

The information content of SCORE model in the evaluation of the total ten-year cardiovascular risk in an isolated sample of 207 males without clinical manifestations of atherosclerosis was investigated. It was revealed that the most of the observations from persons who had attained over a 10-year period of the combined end point, the model qualified incorrectly, which didn’t meet the requirements of individual risk assessment in a limited sample group of males. It is shown that the inclusion of subclinical atherosclerosis markers in SCORE model can significantly improve its sensitivity. At the same time, a group of poor prognosis gets a significant number of observations for individuals free of cardiovascular events due to the high probability of false positive response.

Keywords

• atherosclerosis
• cardiovascular events
• combined endpoint
• score model
• atheroma
• arterial intima- media thickness