The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells

Yibo Fu; Francesca Ricciardiello; Gang Yang; Jiangdong Qiu; Hua Huang; Jianchun Xiao; Zhe Cao; Fangyu Zhao; Yueze Liu; Wenhao Luo; Guangyu Chen; Lei You; Ferdinando Chiaradonna; Lianfang Zheng; Taiping Zhang

doi:10.3390/cells10030497

Cells (Feb 2021)

The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells

Yibo Fu,
Francesca Ricciardiello,
Gang Yang,
Jiangdong Qiu,
Hua Huang,
Jianchun Xiao,
Zhe Cao,
Fangyu Zhao,
Yueze Liu,
Wenhao Luo,
Guangyu Chen,
Lei You,
Ferdinando Chiaradonna,
Lianfang Zheng,
Taiping Zhang

Affiliations

Yibo Fu: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Francesca Ricciardiello: Department of Biotechnology and Bioscience, University of Milano Bicocca, 20126 Milano, Italy
Gang Yang: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Jiangdong Qiu: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Hua Huang: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Jianchun Xiao: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Zhe Cao: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Fangyu Zhao: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Yueze Liu: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Wenhao Luo: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Guangyu Chen: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Lei You: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Ferdinando Chiaradonna: Department of Biotechnology and Bioscience, University of Milano Bicocca, 20126 Milano, Italy
Lianfang Zheng: Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Taiping Zhang: General Surgery Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

DOI: https://doi.org/10.3390/cells10030497
Journal volume & issue: Vol. 10, no. 3
p. 497

Abstract

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The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the prognosis of patients with PC has not been significantly improved. Mitochondria are essential organelles in eukaryotes that evolved from aerobic bacteria. In recent years, many studies have shown that mitochondria play important roles in tumorigenesis and may act as chemotherapeutic targets in PC. In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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