Association of Pulse Pressure Difference and Diabetes Mellitus in Chinese People: A Cohort Study

Abstract

Chunlei Wu, Denhua Ma, Yu Chen Department of Cardiac Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of ChinaCorrespondence: Yu Chen People’s Republic of ChinaEmail [email protected]: Here, we sought to determine the association between pulse pressure difference and the incidence of type 2 diabetes mellitus (T2DM) in Chinese people.Methods: This study involved 211,814 participants among whom 4156 had been diagnosed with T2DM. The correlation between pulse pressure difference and T2DM incidence in Chinese people was determined by multivariate analysis. A smooth curve fitting diagram was then used to explore correlation between pulse pressure difference and T2DM incidence. Finally, the inflection point in the correlation between pulse pressure difference and the T2DM incidence was located by piecewise linear regression.Results: To understand the relationship, adjustments were made for sex, age, total serum cholesterol (TC), fasting blood glucose (FPG), triglyceride (TG), alanine aminotransferase (ALT), family history of diabetes, body mass index (BMI), blood urea nitrogen (BUN), drinking status, and smoking status. Diabetes incidence increased by 0.3% [HR 1.003 (1.001, 1.005), p = 35mmHg, diabetes incidence increased with increasing pulse pressure difference [HR 1.044 (1.042, 1.047) p = < 0.001]. And between pulse pressure difference and fasting blood glucose in the final visit, the blood glucose level increased with the elevation of pulse pressure.Conclusion: The risk of diabetes was lowest at about 35mmHg pulse pressure difference.Keywords: pulse pressure difference, diabetes mellitus incidence, Chinese population, cohort study

Keywords

• pulse pressure difference
• diabetes mellitus incidence
• chinese population
• cohort