Nature Communications (Oct 2019)
Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
- Peter Ulz,
- Samantha Perakis,
- Qing Zhou,
- Tina Moser,
- Jelena Belic,
- Isaac Lazzeri,
- Albert Wölfler,
- Armin Zebisch,
- Armin Gerger,
- Gunda Pristauz,
- Edgar Petru,
- Brandon White,
- Charles E. S. Roberts,
- John St. John,
- Michael G. Schimek,
- Jochen B. Geigl,
- Thomas Bauernhofer,
- Heinz Sill,
- Christoph Bock,
- Ellen Heitzer,
- Michael R. Speicher
Affiliations
- Peter Ulz
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- Samantha Perakis
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- Qing Zhou
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- Tina Moser
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- Jelena Belic
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- Isaac Lazzeri
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- Albert Wölfler
- Department of Internal Medicine, Division of Hematology, Medical University of Graz
- Armin Zebisch
- Department of Internal Medicine, Division of Hematology, Medical University of Graz
- Armin Gerger
- Department of Internal Medicine, Division of Oncology, Medical University of Graz
- Gunda Pristauz
- Department of Obstetrics and Gynecology, Medical University of Graz
- Edgar Petru
- Department of Obstetrics and Gynecology, Medical University of Graz
- Brandon White
- Freenome
- Charles E. S. Roberts
- Freenome
- John St. John
- Freenome
- Michael G. Schimek
- Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz
- Jochen B. Geigl
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- Thomas Bauernhofer
- Department of Internal Medicine, Division of Oncology, Medical University of Graz
- Heinz Sill
- Department of Internal Medicine, Division of Hematology, Medical University of Graz
- Christoph Bock
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Ellen Heitzer
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- Michael R. Speicher
- Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz
- DOI
- https://doi.org/10.1038/s41467-019-12714-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Deregulation of transcription factors is frequently observed in cancer. Here, the authors develop a blood-based approach to map transcription factor binding, revealing both patient-specific and tumour-specific aberrations
