Nature Communications (Jun 2019)

CHML promotes liver cancer metastasis by facilitating Rab14 recycle

  • Tian-Wei Chen,
  • Fen-Fen Yin,
  • Yan-Mei Yuan,
  • Dong-Xian Guan,
  • Erbin Zhang,
  • Feng-Kun Zhang,
  • Hao Jiang,
  • Ning Ma,
  • Jing-Jing Wang,
  • Qian-Zhi Ni,
  • Lin Qiu,
  • Jing Feng,
  • Xue-Li Zhang,
  • Ying Bao,
  • Kang Wang,
  • Shu-Qun Cheng,
  • Xiao-Fan Wang,
  • Xiang Wang,
  • Jing-Jing Li,
  • Dong Xie

DOI
https://doi.org/10.1038/s41467-019-10364-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Metastasis-associated recurrence is a major cause of poor prognosis in hepatocellular carcinoma. Here, the authors show that expression of choroideremia-like (CHML) is elevated and associates with poor prognosis in hepatocellular carcinoma, and mechanistically CHML promotes metastasis in a Rab14-dependent manner.