Nature Communications (Jul 2018)
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure
Abstract
During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component CHMP2A as a phagophore closure regulator.