Nature Communications (Jun 2020)
Iron imaging in myocardial infarction reperfusion injury
- Brianna F. Moon,
- Srikant Kamesh Iyer,
- Eileen Hwuang,
- Michael P. Solomon,
- Anya T. Hall,
- Rishabh Kumar,
- Nicholas J. Josselyn,
- Elizabeth M. Higbee-Dempsey,
- Andrew Tsourkas,
- Akito Imai,
- Keitaro Okamoto,
- Yoshiaki Saito,
- James J. Pilla,
- Joseph H. Gorman,
- Robert C. Gorman,
- Cory Tschabrunn,
- Samuel J. Keeney,
- Estibaliz Castillero,
- Giovanni Ferrari,
- Steffen Jockusch,
- Felix W. Wehrli,
- Haochang Shou,
- Victor A. Ferrari,
- Yuchi Han,
- Avanti Gulhane,
- Harold Litt,
- William Matthai,
- Walter R. Witschey
Affiliations
- Brianna F. Moon
- Department of Bioengineering, University of Pennsylvania
- Srikant Kamesh Iyer
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania
- Eileen Hwuang
- Department of Bioengineering, University of Pennsylvania
- Michael P. Solomon
- Department of Bioengineering, University of Pennsylvania
- Anya T. Hall
- Department of Bioengineering, University of Pennsylvania
- Rishabh Kumar
- Department of Biophysics, University of Pennsylvania
- Nicholas J. Josselyn
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania
- Elizabeth M. Higbee-Dempsey
- Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania
- Andrew Tsourkas
- Department of Bioengineering, University of Pennsylvania
- Akito Imai
- Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Keitaro Okamoto
- Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Yoshiaki Saito
- Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- James J. Pilla
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania
- Joseph H. Gorman
- Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Robert C. Gorman
- Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Cory Tschabrunn
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Samuel J. Keeney
- Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Estibaliz Castillero
- Department of Surgery, Columbia University Irving Medical Center
- Giovanni Ferrari
- Department of Surgery, Columbia University Irving Medical Center
- Steffen Jockusch
- Department of Chemistry, Columbia University
- Felix W. Wehrli
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania
- Haochang Shou
- Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania
- Victor A. Ferrari
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Yuchi Han
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Avanti Gulhane
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania
- Harold Litt
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania
- William Matthai
- Department of Medicine, Penn Presbyterian Medical Center, University of Pennsylvania
- Walter R. Witschey
- Department of Bioengineering, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-020-16923-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Restoration of coronary blood flow after a heart attack may lead to reperfusion injury and pathologic iron deposition. Here, the authors perform magnetic susceptibility imaging showing its association with iron in a large animal model of myocardial infarction during wound healing, and showing feasibility in acute myocardial infarction patients undergoing percutaneous coronary intervention.
