Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity

Abstract

Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and as a target of host antiviral responses. This review highlights the knowledge of adenovirus disassembly and nuclear transport gleaned from structural, biophysical and functional analyses of adenovirus interactions with soluble and membrane-associated host molecules.

Keywords

• adenovirus
• AFM
• capsid disassembly
• integrins
• defensins
• cryoelectron microscopy
• antibody
• neutralization
• nuclear pore
• dynein
• hexon
• penton base
• protein VI
• ts1
• cysteine protease
• nuclear porins
• microtubules
• adenovirus receptors