Methyl-Coenzyme M Reductase and Its Post-translational Modifications

Hao Chen; Qinglei Gan; Chenguang Fan; Chenguang Fan

doi:10.3389/fmicb.2020.578356

Frontiers in Microbiology (Oct 2020)

Methyl-Coenzyme M Reductase and Its Post-translational Modifications

Hao Chen,
Qinglei Gan,
Chenguang Fan,
Chenguang Fan

Affiliations

Hao Chen: Cell and Molecular Biology Program, University of Arkansas, Fayetteville, AR, United States
Qinglei Gan: Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, United States
Chenguang Fan: Cell and Molecular Biology Program, University of Arkansas, Fayetteville, AR, United States
Chenguang Fan: Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, United States

DOI: https://doi.org/10.3389/fmicb.2020.578356
Journal volume & issue: Vol. 11

Abstract

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The methyl-coenzyme M reductase (MCR) is a central enzyme in anaerobic microbial methane metabolism, which consists of methanogenesis and anaerobic oxidation of methane (AOM). MCR catalyzes the final step of methanogenesis and the first step of AOM to achieve the production and oxidation of methane, respectively. Besides a unique nickel tetrahydrocorphinoid (coenzyme F430), MCR also features several unusual post-translational modifications (PTMs), which are assumed to play important roles in regulating MCR functions. However, only few studies have been implemented on MCR PTMs. Therefore, to recapitulate current knowledge and prospect future studies, this review summarizes and discusses studies on MCR and its PTMs.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

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