Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis

Vinicius M. Gadotti; Graciela Andonegui; Zizhen Zhang; Said M'Dahoma; Cristiane H. Baggio; Lina Chen; Lilian Basso; Christophe Altier; Wallace K. MacNaughton; Paul Kubes; Gerald W. Zamponi

iScience (Jun 2019)

Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis

Vinicius M. Gadotti,
Graciela Andonegui,
Zizhen Zhang,
Said M'Dahoma,
Cristiane H. Baggio,
Lina Chen,
Lilian Basso,
Christophe Altier,
Wallace K. MacNaughton,
Paul Kubes,
Gerald W. Zamponi

Affiliations

Vinicius M. Gadotti: Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Corresponding author
Graciela Andonegui: Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Zizhen Zhang: Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Said M'Dahoma: Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Cristiane H. Baggio: Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Lina Chen: Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Lilian Basso: Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Christophe Altier: Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Wallace K. MacNaughton: Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Paul Kubes: Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Gerald W. Zamponi: Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Corresponding author

Journal volume & issue: Vol. 16
pp. 12 – 21

Abstract

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Summary: Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanied by the development of pain and depressive behaviors. Importantly, treatment with the flavonoid luteolin prevented both neuroimmune responses and behavioral abnormalities, suggesting a new potential therapeutic approach for patients with inflammatory bowel diseases. : Pathophysiology; Behavioral Neuroscience; Cellular Neuroscience; Immunity Subject Areas: Pathophysiology, Behavioral Neuroscience, Cellular Neuroscience, Immunity

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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