Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction

M. T. Jeena; L. Palanikumar; Eun Min Go; Inhye Kim; Myoung Gyun Kang; Seonik Lee; Sooham Park; Huyeon Choi; Chaekyu Kim; Seon-Mi Jin; Sung Chul Bae; Hyun Woo Rhee; Eunji Lee; Sang Kyu Kwak; Ja-Hyoung Ryu

doi:10.1038/s41467-017-00047-z

Nature Communications (Jun 2017)

Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction

M. T. Jeena,
L. Palanikumar,
Eun Min Go,
Inhye Kim,
Myoung Gyun Kang,
Seonik Lee,
Sooham Park,
Huyeon Choi,
Chaekyu Kim,
Seon-Mi Jin,
Sung Chul Bae,
Hyun Woo Rhee,
Eunji Lee,
Sang Kyu Kwak,
Ja-Hyoung Ryu

Affiliations

M. T. Jeena: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
L. Palanikumar: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Eun Min Go: School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST)
Inhye Kim: Graduate School of Analytical Science and Technology, Chungnam National University
Myoung Gyun Kang: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Seonik Lee: Department of Biological Engineering, Ulsan National Institute of Science and Technology (UNIST)
Sooham Park: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Huyeon Choi: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Chaekyu Kim: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Seon-Mi Jin: Graduate School of Analytical Science and Technology, Chungnam National University
Sung Chul Bae: Department of Biological Engineering, Ulsan National Institute of Science and Technology (UNIST)
Hyun Woo Rhee: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Eunji Lee: Graduate School of Analytical Science and Technology, Chungnam National University
Sang Kyu Kwak: School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST)
Ja-Hyoung Ryu: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)

DOI: https://doi.org/10.1038/s41467-017-00047-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to apoptosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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