Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling

Bhupinder Pal; Yunshun Chen; François Vaillant; Paul Jamieson; Lavinia Gordon; Anne C. Rios; Stephen Wilcox; Naiyang Fu; Kevin He Liu; Felicity C. Jackling; Melissa J. Davis; Geoffrey J. Lindeman; Gordon K. Smyth; Jane E. Visvader

doi:10.1038/s41467-017-01560-x

Nature Communications (Nov 2017)

Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling

Bhupinder Pal,
Yunshun Chen,
François Vaillant,
Paul Jamieson,
Lavinia Gordon,
Anne C. Rios,
Stephen Wilcox,
Naiyang Fu,
Kevin He Liu,
Felicity C. Jackling,
Melissa J. Davis,
Geoffrey J. Lindeman,
Gordon K. Smyth,
Jane E. Visvader

Affiliations

Bhupinder Pal: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
Yunshun Chen: Department of Medical Biology, The University of Melbourne
François Vaillant: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
Paul Jamieson: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
Lavinia Gordon: Australian Genome Research Facility, The Walter and Eliza Hall Institute of Medical Research
Anne C. Rios: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
Stephen Wilcox: Systems Biology & Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research
Naiyang Fu: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
Kevin He Liu: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
Felicity C. Jackling: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
Melissa J. Davis: Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
Geoffrey J. Lindeman: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research
Gordon K. Smyth: Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
Jane E. Visvader: ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-017-01560-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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The mammary epithelium comprises two cell lineages but the heterogeneity amongst these during development is unclear. Here, the authors report single-cell RNA sequencing of the mouse mammary epithelium at four developmental stages, revealing diversity in both compartments and a transcriptional shift with puberty onset.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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