Nature Communications (Aug 2016)
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
- Michael J. D. Daniels,
- Jack Rivers-Auty,
- Tom Schilling,
- Nicholas G. Spencer,
- William Watremez,
- Victoria Fasolino,
- Sophie J. Booth,
- Claire S. White,
- Alex G. Baldwin,
- Sally Freeman,
- Raymond Wong,
- Clare Latta,
- Shi Yu,
- Joshua Jackson,
- Nicolas Fischer,
- Violette Koziel,
- Thierry Pillot,
- James Bagnall,
- Stuart M. Allan,
- Pawel Paszek,
- James Galea,
- Michael K. Harte,
- Claudia Eder,
- Catherine B. Lawrence,
- David Brough
Affiliations
- Michael J. D. Daniels
- Faculty of Biology, Medicine and Health, University of Manchester
- Jack Rivers-Auty
- Faculty of Biology, Medicine and Health, University of Manchester
- Tom Schilling
- St. George’s University of London, Institute for Infection and Immunity
- Nicholas G. Spencer
- St. George’s University of London, Institute for Infection and Immunity
- William Watremez
- Manchester Pharmacy School, University of Manchester
- Victoria Fasolino
- Manchester Pharmacy School, University of Manchester
- Sophie J. Booth
- Faculty of Biology, Medicine and Health, University of Manchester
- Claire S. White
- Faculty of Biology, Medicine and Health, University of Manchester
- Alex G. Baldwin
- Manchester Pharmacy School, University of Manchester
- Sally Freeman
- Manchester Pharmacy School, University of Manchester
- Raymond Wong
- Faculty of Biology, Medicine and Health, University of Manchester
- Clare Latta
- Faculty of Biology, Medicine and Health, University of Manchester
- Shi Yu
- Faculty of Biology, Medicine and Health, University of Manchester
- Joshua Jackson
- Manchester Pharmacy School, University of Manchester
- Nicolas Fischer
- SynAging SAS, 24–30 rue Lionnois
- Violette Koziel
- SynAging SAS, 24–30 rue Lionnois
- Thierry Pillot
- SynAging SAS, 24–30 rue Lionnois
- James Bagnall
- Faculty of Biology, Medicine and Health, University of Manchester
- Stuart M. Allan
- Faculty of Biology, Medicine and Health, University of Manchester
- Pawel Paszek
- Faculty of Biology, Medicine and Health, University of Manchester
- James Galea
- Division of Neuroscience, Ninewells Medical School, University of Dundee
- Michael K. Harte
- Manchester Pharmacy School, University of Manchester
- Claudia Eder
- St. George’s University of London, Institute for Infection and Immunity
- Catherine B. Lawrence
- Faculty of Biology, Medicine and Health, University of Manchester
- David Brough
- Faculty of Biology, Medicine and Health, University of Manchester
- DOI
- https://doi.org/10.1038/ncomms12504
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for therapeutic effect in rodent models of Alzheimer disease.
