Frontiers in Immunology (Feb 2021)

Natural Polyphenols as Targeted Modulators in Colon Cancer: Molecular Mechanisms and Applications

  • Jing Long,
  • Jing Long,
  • Peng Guan,
  • Peng Guan,
  • Xian Hu,
  • Xian Hu,
  • Lingyuan Yang,
  • Liuqin He,
  • Liuqin He,
  • Qinlu Lin,
  • Feijun Luo,
  • Jianzhong Li,
  • Xingguo He,
  • Zhiliang Du,
  • Tiejun Li

DOI
https://doi.org/10.3389/fimmu.2021.635484
Journal volume & issue
Vol. 12

Abstract

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Colon cancer commonly develops from long-term chronic inflammation in the intestine and seriously threatens human health. Natural polyphenols have been valued as a crucial regulator of nutrient metabolism and metabolic diseases, owing to their anti-inflammatory and antioxidant functions and the ability to maintain a balance between gut microbes and their hosts. Notably, experimental and clinical evidence has shown that natural polyphenols could act as a targeted modulator to play a key role in the prevention or treatment of colon cancer. Thus, in this review, we summarized recent advances in the possible regulatory mechanism and the potential application of natural polyphenols in colon cancer, which might be regarded as a novel platform for the colon cancer management.

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