Multidimensional heritability analysis of neuroanatomical shape

Tian Ge; Martin Reuter; Anderson M. Winkler; Avram J. Holmes; Phil H. Lee; Lee S. Tirrell; Joshua L. Roffman; Randy L. Buckner; Jordan W. Smoller; Mert R. Sabuncu

doi:10.1038/ncomms13291

Nature Communications (Nov 2016)

Multidimensional heritability analysis of neuroanatomical shape

Tian Ge,
Martin Reuter,
Anderson M. Winkler,
Avram J. Holmes,
Phil H. Lee,
Lee S. Tirrell,
Joshua L. Roffman,
Randy L. Buckner,
Jordan W. Smoller,
Mert R. Sabuncu

Affiliations

Tian Ge: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School
Martin Reuter: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School
Anderson M. Winkler: Centre for Functional MRI of the Brain (FMRIB), University of Oxford
Avram J. Holmes: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School
Phil H. Lee: Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital
Lee S. Tirrell: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School
Joshua L. Roffman: Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School
Randy L. Buckner: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School
Jordan W. Smoller: Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital
Mert R. Sabuncu: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School

DOI: https://doi.org/10.1038/ncomms13291
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

Neuroanatomical shape measurements are multidimensional geometric descriptions of brain structure. This study develops multivariate heritability analysis methods and examines structural brain MRI scans and genetic data to estimate the heritability of neuroanatomical shape.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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