Iranian South Medical Journal (Apr 2015)
Investigation of E-cadherin expression in Peripheral Blood of patients with breast cancer in a population from southern Iran
Abstract
Background: Breast cancer is the most common malignancy in women, and is considered as the second causative factor in cancer mortality. E – Cadherin is a transmember glycoprotein and play a essential role in cell-cell adhesion .It seems that E-cadherin Gene expression can plays a role in suppressor of invasion and metastasistumor . The aim of this study was to evaluate the correlation of E-cadherin Gene expression with breast cancer in the women population of southern Iran. Materials and Methods: 30 patients and 30 healthy individuals as control participated in this case-control study. mRNA extracted from peripheral blood. Real Time PCR technique was used to determine the Gene expression. The statistical analysis was performed by the software SPSS and Mannwithny test . Results: The results indicated that there is no significant difference in level of E- cadherin Gene expression in patients with breast cancer and the control group (Pv>0.05). Furthermore, we found no significant correlation between the E- cadherin Gene expression with the clinicopathological factors in the patients. Conclusion: it seems that E- cadherin Gene expression, plays no important role in increasing the susceptibility of women to breast cancer in the population of southern Iran.
