Neutrophil-derived reactive oxygen species promote tumor colonization

Jianghong Zhong; Qijing Li; Huqiao Luo; Rikard Holmdahl

doi:10.1038/s42003-021-02376-8

Communications Biology (Jul 2021)

Neutrophil-derived reactive oxygen species promote tumor colonization

Jianghong Zhong,
Qijing Li,
Huqiao Luo,
Rikard Holmdahl

Affiliations

Jianghong Zhong: Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
Qijing Li: Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
Huqiao Luo: Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute
Rikard Holmdahl: Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute

DOI: https://doi.org/10.1038/s42003-021-02376-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 7

Abstract

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Zhong et al. investigate how mutations in the NOX2 subunit Ncf1 lead to reduced ROS formation and affect B16F10 lung metastasis. The study highlights neutrophils as key to detrimental ROS-formation and suggest the involvement of IL-1 beta and RAGE.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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